Cystatin B antibody

Name Cystatin B antibody
Supplier Biorbyt
Catalog orb76170
Prices $340.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Applications WB
Species Reactivities Rat
Antigen A synthetic peptide corresponding to a sequence in the middle region of mouse CSTB(62-77aa DKCVHLRVFQPLPHEN), different from the related rat sequence by two amino acids.
Purity/Format Lyophilized.Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Description Rabbit Polyclonal to Cystatin B. Cystatin B(CSTB),also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.
Gene Cstb
Conjugate Unconjugated
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