SPRYD2 Antibody
| Name | SPRYD2 Antibody |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 254492 |
| Prices | $292.00 |
| Sizes | 100 µg |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Applications | ELISA ICC/IF IHC WB |
| Species Reactivities | Human |
| Antigen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SPRYD2. |
| Purity/Format | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| Description | SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy. |
| Gene | CMYA5 |
| Supplier Page | Shop |
Product images
Western blot analysis of SPRYD2 in rat brain tissue lysate with SPRYD2 Antibody (Cat. No. 254492) at (A) 1 and (B) 2 ug/ml.
SPRYD2 staining in mouse brain. Paraffin-embedded mouse brain is stained with SPRYD2 Antibody (Cat. No. 254492) used at 2.5 ug/ml.
Immunofluorescent staining of SPRYD2 in mouse brain with SPRYD2 Antibody (Cat. No. 254492) used at 20 ug/ml.