transferrin-PAP immunotoxin

• Supplier: Creative Biolabs
• Catalog: AGTO-G074P
• Host: Human
• Applications: Cytotoxic Assay FA
• Species Reactivities: Human
• Description: This immunotoxin was achieved by conjugating/fusing the transferrin to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of myelogenous leukemia.
• Gene: BDP1