transferrin-Sap immunotoxin

• Supplier: Creative Biolabs
• Catalog: AGTO-G074S
• Host: Human
• Applications: Cytotoxic Assay FA
• Species Reactivities: Human
• Description: This immunotoxin was achieved by conjugating/fusing the transferrin to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of myelogenous leukemia.
• Gene: BDP1