The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase - The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Nature. 2014 Jun 19;510(7505):397-401.
Anti-ATP5O antibody (ab91400) at 1/100 dilution + 293 cell lysate at 35 µg