APETx2
| Name | APETx2 |
|---|---|
| Supplier | Abcam |
| Catalog | ab141849 |
| Chemical Name | GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD (Modification: Disulfide bridges: 4-37, 6-30 and 20-38) |
| Formula | C196H280N54O61S6 |
| Molecular Weight | 4561.05 |
| Purity | > 98% |
| Description | Selective, reversible ASIC3 channel blocker |
| Supplier Page | Shop |
Product images
APETx2 blocks inward currents of ASIC3 channels expressed in Xenopus oocytes. Membrane potential was held at 5 mV and whole cell current was continuously recorded. ASIC3 currents were elicited by rapid exposure to pH 5 in physiological solution every 20 sec. 1 µM APETx2 (ab141849) was introduced into the bath via perfusion, resulting in a reversible inhibition of the pH dependent inward transients.