Name |
Obatoclax, Methanesulfonate Salt
|
Supplier |
Biorbyt
|
Catalog |
orb153622
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Prices |
$315.00, $374.00, $451.00, $587.00, $935.00, $1,369.00, $1,964.00, $3,638.00
|
Sizes |
5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
|
Cas Number |
[803712-79-0]
|
Pubchem |
46930996
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Chemical Name |
(2E)-2-[(5Z)-5-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-4-methoxypyrrol-2-ylidene]indole;methanesulfonicacid
|
Formula |
C20H19N3O•CH4SO3
|
Molecular Weight |
413.49 g/mol
|
Purity |
>99% pure
|
Description |
Obatoclax (GX15-070), is a novel small-molecule inhibitor of antiapoptotic Bcl-2 proteins homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. Obatoclax inhibited influenza A virus (IAV) uptake and demonstrated broad-spectrum antiviral activity. Obatoclax is an experimental drug candidate for the treatment of various types of cancer like leukemia, lymphoma, myelofibrosis, and mastocytosis.
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