RN486

• Supplier: Creative Biomart
• Catalog: EI-1159
• Cas Number: 1242156-23-5
• Chemical Name: 6-cyclopropyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquinolin-1(2H)-one 2,2,2-trifluoroacetate
• Formula: C35H35FN6O3.CF3COOH
• Molecular Weight: 720.71
• Purity: > 95%
• Description: RN486 displayed functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC = 21.0 nM).