JAK2 Inhibitor V, Z3

• Supplier: Creative Biomart
• Catalog: EI-1065
• Cas Number: 195371-52-9
• Chemical Name: 2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
• Formula: C23H24N2O
• Molecular Weight: 344.5
• Purity: ≥97% by HPLC
• Description: A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 μM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays