| Name | GSK-25 |
|---|---|
| Supplier | Creative Biomart |
| Catalog | EI-1129 |
| Cas Number | 874119-56-9 |
| Chemical Name | 4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol -5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide |
| Formula | C24H16Cl2F2N6O |
| Molecular Weight | 513.33 |
| Purity | > 95% |
| Description | GSK-25 has promising oral bioavailability (49% in rat and 19% in monkey) a good half-life (1.8h in rat and 2.2h in monkey) and maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50=398nM, p70S6K IC50=1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
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