PIM-Kinase Inhibitor IX, SGI-1776 - Calbiochem
| Name | PIM-Kinase Inhibitor IX, SGI-1776 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 526528 |
| Formula | C₂₀H₂₂F₃N₅O•2H₂SO₄ |
| Purity | ≥99% by HPLC |
| Description | A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC 50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases |
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