MKLP-2 Inhibitor, Paprotrain - Calbiochem

• Supplier: EMD Millipore
• Catalog: 512533
• Formula: C₁₆H₁₁N₃
• Purity: ≥98% by HPLC
• Description: A cell-permeable acrylonitrile compound that inhibits the kinesin-6 family member MKLP-2 (Mitotic kinesin-like protein 2; IC 50 against basal and microtubule-/MT-stimulated ATPase activity = 1.35 and 0.83 µM, respectively) in a reversible, ATP-uncompetitive ( K i = 3.36 µM), and MT-noncompetitive ( K i = 1.6 µM) manner, with little effect against the ATPase activity of 12 other kinesins (≤20% inhibition at 50 µM), including the close related MKLP-1 and MPP1 (M-phase phosphoprotein 1)