β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem
| Name | β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 219332 |
| Formula | C₂₃H₂₆N₂O₂S |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable oxazole compound that acts as a selective CRT (β-catenin responsive transcription) inhibitor (IC 50 = 8.2 nM against Wnt3a-dependent SuperTopFlash STF16-luc reporter activity in HEK293 cultures) by interfering with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, while exhibiting much reduced activity against Hedgehog, Jak/Stat, or Notch signaling pathway-dependent transcription activation |
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