Wnt Pathway Inhibitor XII - Calbiochem

• Supplier: EMD Millipore
• Catalog: 681677
• Formula: C₁₆H₁₅F₂N
• Purity: ≥95% by HPLC
• Description: A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis (IC 50 =4.9 µM; [L-Met] = [ATP] = 1 mM, [MAT2A] = 10 µg/mL; 20 min preincubation prior to 30 min reaction) by targeting SAM-binding pocket at the MAT2A dimer interface