PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
| Name | PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 529581 |
| Cas Number | 221244-14-0 |
| Formula | C₂₀H₂₁N₅ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC 50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl) |
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