ERK Inhibitor III - CAS 331656-92-9 - Calbiochem

Name ERK Inhibitor III - CAS 331656-92-9 - Calbiochem
Supplier EMD Millipore
Catalog 328009
Cas Number 331656-92-9
Formula C₁₂H₁₀N₆O₅
Purity ≥85% by HPLC
Description A cell-permeable furanyl-nitroaminoguanidine ERK-binding (K D of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
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