Name | ERK Inhibitor III - CAS 331656-92-9 - Calbiochem |
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Supplier | EMD Millipore |
Catalog | 328009 |
Cas Number | 331656-92-9 |
Formula | C₁₂H₁₀N₆O₅ |
Purity | ≥85% by HPLC |
Description | A cell-permeable furanyl-nitroaminoguanidine ERK-binding (K D of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells. |
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