TNP-470 - CAS 129298-91-5 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 654270
• Cas Number: 129298-91-5
• Formula: C₁₉H₂₈CINO₆
• Purity: ≥97% by HPLC
• Description: A cell-permeable Fumagillin (Cat. No. 344845 ) analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC 50 = 1 nM against human MetAP2) by covalently modifying MetAP2 active site histidine (aa 231 in human/mouse/rat; aa 174 in yeast) via its epoxide group, without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2α phosphorylation

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