| Description |
A cell-permeable 2,6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1,4,5)P 3 (Cat. Nos. 407123 & 407137 ) to Ins(1,3,4,5)P 4 (Cat. No. 407126 ) by IP3K (IC 50 = 18 µM; [ATP] = 10 μM), acts in fact as a much more effective inhibitor against the IP6K1/2/3-catalyzed conversion of InsP 6 (Cat. No. 407125 ) to 5-[PP]- InsP 6 or InsP 7 (IC 50 = 0.47 μM against IP6K1; [ATP] = 1 mM) due to a much higher affinity of ATP toward IP3K than IP6K ( K m of ATP for the respective enzymes = 0.01 vs 1000 μM)
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