Name | PIM3 Kinase Inhibitor VII, M-110 - Calbiochem |
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Supplier | EMD Millipore |
Catalog | 526526 |
Formula | C₂₂H₂₈ClN₅O₃ |
Purity | ≥97% by HPLC |
Description | A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (K i = 0.3 µM), and highly isoform-selective PIM inhibitor (IC 50 = 2.5, 2.5, and 0.047 µM against PIM1, PIM2, and PIM3, respectively, with PIMtide as substrate, [ATP] = 10 µM), while affecting CK2α2 only at much higher concentrations (IC 50 = 5 µM, [ATP] = 10 µM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition; [M-110] = 5 µM) |
Supplier Page | Shop |