PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem
| Name | PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 528113 |
| Cas Number | 663619-89-4 |
| Formula | C₂₁H₂₄N₄O₂ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC 50 = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo . |
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