ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem
| Name | ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 324732 |
| Cas Number | 928207-02-7 |
| Formula | C₁₅H₁₀N₄O |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC 50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC 50 of 30.9 µM. |
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