Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem
| Name | Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 553511 |
| Cas Number | 1090893-12-1 |
| Formula | C₂₀H₂₁N₃O₅S |
| Purity | ≥93% by HPLC |
| Description | AA cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1 |
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