HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem
| Name | HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 382177 |
| Cas Number | 6953-61-3 |
| Formula | C₁₁H₉NO₂ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable aryl-hydroxamate compound that selectively inhibits the activity of HDAC8 (IC 50 = 14 µM) over class I HDAC1 and class II HDAC6 (IC 50 >100 µM) without affecting the overall H4 acetylation level in BE(2)-C cultures even at concentrations as high as 20 µM. HDAC8 downregulation by either Compound 2 (10 to 40 µM) or siRNA in neuroblastoma cultures is reported to result in growth inhibition accompanied by neurite-like morphological changes |
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