JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
| Name | JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 420144 |
| Cas Number | 40045-50-9 |
| Formula | C₅H₃N₅O₂S₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable non-peptidyl thiazolyl-thiadiazole alternative to pepJIP1 (TI-JIP1 153-163 ) and TAT-pepJIP1 (Cat. Nos. 420133 & 420134, respectively) as a JIP-docking site-targeting (IC 50 = 239 nM against pepJIP1 binding to JNK1) and substrate-competitive JNK inhibitor (IC 50 = 700 nM against ATF2 phosphorylation by JNK1), while exhibiting little activity (IC 50 >50 µM) toward p38α, Akt, furin, or lethal factor |
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