Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem
| Name | Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 189410 |
| Cas Number | 331771-20-1 |
| Formula | C₂₉H₃₁N₅O₄ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC 50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC 50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC 50 > 10 µM for Cdk1/2/4, Plk1, Chk1) |
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