γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem
| Name | γ-Secretase Inhibitor XXII , Aβ42-Selective, CS-1 - CAS 1210283-33-2 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 565791 |
| Cas Number | 1210283-33-2 |
| Formula | C₂₅H₁₃F₃O₆ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable di-coumarin compound that selectively inhibits γ-secretase-mediated production of Aβ42 over Aβ38, Aβ40, and Notch1 both in cell-free APP cleavage assays (IC 50 = 0.07, 0.71, 0.31, and 1.77 µM, respectively) and in human and murine cultures (100% blockage of Aβ42 production and no effect against the rest at 30 µM) by altering the S1' and S3' pockets within the presenilin substrate binding site via an allosteric, non-substrate-competitive mechanism. |
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