| Description |
A cell-permeable salicylanilide that, in addition to its well-known antihelmintic efficacy and use in tapeworm treatment, acts as a mammalian mTORC1, but not mTORC2, signaling inhibitor mechanistically distinct from rapamycin (Cat. Nos. 553210 , 553211 , & 553212 ), causing MCF-7 autophagy activation under nutrient-rich conditions (by 15-fold with 4h 10 µM treatment), SH-SY5Y lysosome redistribution (10 µM for 8 h), and dissipation/clearance of ubiquinated protein aggregates upon proteasome inhibition in a reversible, time- and dose-dependent manner
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