Name | Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem |
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Supplier | EMD Millipore |
Catalog | 324623 |
Cas Number | 909250-29-9 |
Formula | C₁₄H₁₁FN₂OS |
Purity | ≥99% by HPLC |
Description | A cell-permeable Monastrol (Cat. No. 475879 ) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC 50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC 50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively) |
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