LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem
| Name | LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 489476 |
| Cas Number | 927019-63-4 |
| Formula | C₁₅H₄₀Cl₄N₈ |
| Purity | ≥95% by HPLC |
| Description | A bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro , and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells |
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