Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
| Name | Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 217708 |
| Cas Number | 71203-35-5 |
| Formula | C₂₂H₂₁N₃O₃S |
| Purity | ≥99% by HPLC |
| Description | A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC 50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC 50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant) |
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