TGF-β RI Kinase Inhibitor IX - Calbiochem

Name TGF-β RI Kinase Inhibitor IX - Calbiochem
Supplier EMD Millipore
Catalog 616463
Formula C₁₈H₁₈N₄O₃S
Purity ≥95% by HPLC
Description A cell-permeable pyridinyloxypyridine compound that acts as a potent and highly selective inhibitor against TGFβ RI/ALK5 (IC 50 = 72 nM, [ATP] = 1 mM) by targeting both the ATP-binding site and the “selectivity pocket”, while exhibiting much reduced or little activity against a panel of 75 other kinases (IC 50 <1 µM)
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