TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem
| Name | TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 616459 |
| Cas Number | 356559-20-1 |
| Formula | C₂₁H₂₁N₅ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable quinoxaline compound that acts as a potent, highly selective, ATP-competitive inhibitor against type I TGF-β receptor TβR-I/ALK5 (IC 50 = 14.3 nM), while exhibiting 4-fold less potency toward ALK4 (IC 50 = 58.5 nM) and little or no activity against ALK2/3/6 and a panel of 26 other commonly studied kinases (≤29% inhibition at 10 µM) |
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