LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem
| Name | LIM Kinase Inhibitor I, LIMKi 3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 435930 |
| Cas Number | 1338247-35-0 |
| Formula | C₁₇H₁₄Cl₂F₂N₄OS |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC 50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC 50 ~ 1 µM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC 50 >10 µM in A549 proliferation and colony formation assays) |
| Supplier Page | Shop |
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