PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem
| Name | PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 528121 |
| Cas Number | 853910-02-8 |
| Formula | C₂₈H₂₁N₅ |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable imidazoquinoline compound that acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor (IC 50 = 56, 446, 35, 117, and 245 nM against p110α, p110β, p110δ, p110γ, and PDK1, respectively), displaying much reduced potency against VEGFR1 (IC 50 = 2.56 µM) and little or no activity toward a panel of 15 other kinases (IC 50 >10 µM) |
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