Chk2 Inhibitor, PV1019 - Calbiochem
| Name | Chk2 Inhibitor, PV1019 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 220488 |
| Formula | C₁₈H₁₇N₇O₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable nitroindolo-guanidinohydrazone compound that acts as a potent, ATP-competitive, and highly selective Chk2 inhibitor (IC 50 = 138 and 570 nM against the phosphorylation of histone H1 by Chk2 in the presence of 10 µM and 1 mM of ATP, respectively), while exhibiting much reduced or no activity against a panel of 52 other cellular kinases, including Chk1 (IC 50 = 15.73 and 55 µM against substrate phosphorylation and Chk1 autophosphorylation with 10 µM ATP) |
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