HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem
| Name | HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 382185 |
| Cas Number | 848354-66-5 |
| Formula | C₂₀H₂₆N₂O₂S₂ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC 50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA's hydroxamate as the active-site zinc-targeting group |
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