MNK1/2 Inhibitor II, ETP-45835 - Calbiochem
| Name | MNK1/2 Inhibitor II, ETP-45835 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 454862 |
| Formula | C₁₃H₁₆N₄•2HCl |
| Purity | ≥98% by HPLC |
| Description | A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC 50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against a panel of 24 other kinases (≤15% inhibition at 5 µM), including MNK upstream kinases B-Raf, ERK1, MEK1, and p38α |
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