PTP Inhibitor XXXI, II-B08 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 565852
• Formula: C₃₃H₂₇N₅O₄
• Purity: ≥98% by HPLC
• Description: A cell-permeable indolo-salicylic acid compound that is shown to target SHP2 catalytic domain and inhibit SHP2-catalyzed pNPP hydrolysis (IC 50 = 5.5 µM) in a reversible and non-competitive manner ( K i = 5.2 µM), exhibiting 2.6- to 5.7-fold selectivity over PTP1B, SHP1, FAP1, Lyp, CD45, and LMWPTP (IC 50 = 14.3, 15.7, 20.3, 25.0, 30.0, and 31.1 µM, respectively) and >9-fold selectivity over Cdc14A, HePTP, LAR, PTPα, and VHR (IC 50 >50 µM)

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