Ack1 Inhibitor, AIM-100 - CAS 873305-35-2 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 104833
• Cas Number: 873305-35-2
• Formula: C₂₃H₂₁N₃O₂
• Purity: ≥98% by Chiral HPLC Enantiomeric excess (ee):
• Description: A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC 50 = 22 nM) and effectively prevents receptor-mediated Ack1 activation (>90% of 10 ng/mL EGF-induced Ack1 Tyr284 phosphorylation in MEF and LAPC4 cells with 16 h 800 nM inhibitor pretreatment), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC 50 = 346.7, 432.3, 705.9 and 871.7 nM, respectively) and no inhibitory activity toward 25 other kinases

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