CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem
| Name | CD40-TRAF6 Signaling Inhibitor, 6877002 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 530352 |
| Formula | C₁₇H₁₇NO |
| Purity | ≥95% by NMR |
| Description | A cell-permeable propenone compound that disrupts TNF receptor-associated factor 6 (TRAF6) and CD40 coupling by targeting TRAF6 via direct affinity interaction (K d = 97 µM), effectively inhibiting LPS-induced NF-κB activation in murine macrophage RAW264.7 (IC 50 15.9 µM; drug treatment starts 1 h prior to 2 h CD40 expression induction by LPS) as well as anti-CD40 antibody FGK45-stimulated IL-1β expression (IC 50 < 10 µM; drug treatment starts 1 h prior to 6 h antibody stimulation) |
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