BCRP Inhibitor IV, YHO-13351 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 197228
• Formula: C₂₆H₃₃N₃O₄S•CH₃SO₃H
• Purity: ≥97% by HPLC
• Description: An in vivo bioavailable (~87%; t 1/2 < 5 mins. during p.o. and i.v. administration) and highly water soluble ( >100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227 ) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.).

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