γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
| Name | γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 565793 |
| Cas Number | 290315-45-6 |
| Formula | C₂₄H₂₁ClF₃NO₄S |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable sulfonamide compound that preferentially inhibits γ-secretase activity toward APP CTF over Notch-1 (IC 50 against APP SW CTF and murine ΔE-Notch processing = 7.1 and 105.9 nM, respectively, in HEK293) in a presenillin 1-/PS1-selective manner (IC 50 = 8 and 308 nM against APP SW processing in PS1 -/- PS2 -/- MEF expressing human PS1 and PS2, respectively) |
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