MK-886 - CAS 118414-82-7 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 475889
• Cas Number: 118414-82-7
• Formula: C₂₇H₃₃ClNO₂S·Na
• Purity: ≥99% by TLC
• Description: A cell-permeable, orally active NSAID (nonsteroidal antiinflammatory drug) that blocks cellular Cox pathway PGE2 (prostaglandin E 2 ) production by inhibiting COX-1 and mPGES-1 (microsomal PGE 2 synthase-1), but not COX-2, activity (IC 50 = 8, 2, and 58 µM, respectively), as well as suppresses cellular 5-LO (5-Lypoxygenase; Cat. No. 437996 ) pathway activation by inhibiting FLAP (5-LO-activating protein), rather than 5-LO, activity (<10% by 1 µM MK-886)

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