Autotaxin Inhibitor III, PF-8380 - CAS 1144035-53-9 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 189512
• Cas Number: 1144035-53-9
• Formula: C₂₂H₂₁Cl₂N₃O₅
• Purity: ≥95% by HPLC
• Description: An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC 50 = 2.8 and 1.7 nM for recombinant human enzyme-β isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively; 1.16 and 1.15 nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC; 101 nM for human whole blood}

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