OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 499635
• Cas Number: 189197-69-1
• Formula: C₂₃H₂₇BrFNO₂•C₄H₄O₄
• Purity: ≥95% by HPLC
• Description: An orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC 50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC 50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene