Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
| Name | Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 528283 |
| Cas Number | 40647-02-7 |
| Formula | C₉H₄N₄O₄S |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable b enzo t hiazolo-N- o xide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC 50 = 8.0 µM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 µM) |
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