MDM2 Inhibitor VII, MEL23 - Calbiochem
| Name | MDM2 Inhibitor VII, MEL23 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 373227 |
| Formula | C₁₉H₂₂N₄O₃ |
| Purity | ≥95% by HPLC |
| Description | A cell-permeable tetrahydro-β-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, with 100 µM inhibitor), without affecting Mdm2-MdmX complex formation or the activity of Roc1-Cul1 and BRCA1-BARD1, two other ligase complexes that also utilize UbcH5C as the Ub-conjugating enzyme |
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