Hypothemycin - CAS 76958-67-3 - Calbiochem
| Name | Hypothemycin - CAS 76958-67-3 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 401011 |
| Cas Number | 76958-67-3 |
| Formula | C₁₉H₂₂O₈ |
| Purity | ≥97% by HPLC |
| Description | A cell-permeable cis -enone resorlic acid lactone (RAL) and (5 Z )-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCµ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM) |
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