Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem
| Name | Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 528281 |
| Cas Number | 775294-82-1 |
| Formula | C₂₄H₂₇ClN₂O₄ |
| Purity | ≥94% by HPLC |
| Description | A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC 50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC 50 >66 µM), Plk3 (IC 50 = 875 nM), and aurora A kinase (no detectable effect) |
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