PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem
| Name | PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem |
|---|---|
| Supplier | EMD Millipore |
| Catalog | 521276 |
| Cas Number | 850717-64-5 |
| Formula | C₁₅H₁₄N₄O₂ |
| Purity | ≥95% by HPLC (sum of two isomers) |
| Description | A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDK1 inhibitor (IC 50 = 6 nM) and effectively suppresses cellular Akt Thr 308 phosphorylation level in PC-3 cultures (IC 50 ≤1 µM), while affecting PKA (IC 50 = 1.6 µM) and 7 other kinases (IC 50 ≥600 nM) only at much higher concentrations |
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